Quinoline-8-sulfonyl choride
8-quinolinesulfonyl chloride
CAS: 18704-37-5;917102-35-3
Molecular Formula: C9H6ClNO2S
Quinoline-8-sulfonyl choride - Names and Identifiers
| Name | 8-quinolinesulfonyl chloride |
| Synonyms | ART-CHEM-BB B019400 8-quinolinesulfonyl chloride Quinoline-8-sulfonyl choride 8-QUINOLINESULPHONYL CHLORIDE QUINOLINE-8-SULFONYL CHLORIDE Quinoline-8-sulphonyl chloride QUINOLINE-8-SULPHONYL CHLORIDE 4-bromo-3-tert-butyl-1H-pyrazole 2,2,2-trichloroethyl phosphorodichloridate |
| CAS | 18704-37-5 917102-35-3 |
| EINECS | 242-515-5 |
| InChI | InChI=1/C7H11BrN2/c1-7(2,3)6-5(8)4-9-10-6/h4H,1-3H3,(H,9,10) |
Quinoline-8-sulfonyl choride - Physico-chemical Properties
| Molecular Formula | C9H6ClNO2S |
| Molar Mass | 227.67 |
| Density | 1.483±0.06 g/cm3(Predicted) |
| Melting Point | 126-129°C(lit.) |
| Boling Point | 306°C |
| Flash Point | 306°C |
| Solubility | methanol: soluble10mg/mL, clear, colorless to light yellow |
| Vapor Presure | 0.012mmHg at 25°C |
| Appearance | powder to crystal |
| Color | White to Orange to Green |
| BRN | 156347 |
| pKa | 0?+-.0.17(Predicted) |
| Storage Condition | Inert atmosphere,2-8°C |
| Sensitive | Moisture Sensitive |
| Refractive Index | 1.535 |
Quinoline-8-sulfonyl choride - Risk and Safety
| Hazard Symbols | C - Corrosive |
| Risk Codes | 34 - Causes burns |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) S27 - Take off immediately all contaminated clothing. |
| UN IDs | UN 3261 8/PG 2 |
| WGK Germany | 3 |
| RTECS | VC2830000 |
| FLUKA BRAND F CODES | 3-10-21 |
| HS Code | 29334990 |
| Hazard Class | 8 |
| Packing Group | III |
Quinoline-8-sulfonyl choride - Reference Information
| NIST chemical information | information provided by: webbook.nist.gov (external link) |
| Application | quinoline-8-sulfonyl chloride is an organic intermediate, it can be prepared by reacting 8-quinoline sulfonic acid with thionyl chloride. 8-quinoline sulfonic acid can be used for the preparation of fasudil hydrochloride with genotoxic impurities of 8-quinoline sulfonic acid methyl ester and 8-quinoline sulfonic acid ethyl ester. |
| preparation | 1g of dehydrated quinoline (60g,0.46mol) fumed H2SO4(30% SO 3,120mL) was added dropwise to an ice-cold flask. The temperature of the reaction mixture was maintained below 90 °c during the addition. The resulting dark solution was heated at 90 °c for 40 hours and then cooled to room temperature. Then poured carefully into ice cold H2O(500ml). The colorless prisms formed were collected by filtration, washed with water and dried to give pure 8-quinolinesulfonic acid. A portion of 8-quinolinesulfonic acid (20g,0.088mol) was added to PCl5(20g,0.096mol). The resulting mixture was refluxed at 145 °c for 1 hour and then cooled to room temperature. And extracted with CHCl3(3 x 30ml). The combined organic fractions were evaporated in vacuo and the crude residue was recrystallized from benzene-petroleum ether (B. P. 40-60 °c) to give 12.6g of pure quinoline-8-sulfonyl chloride. |
| Use | a coupling agent in the synthesis of oligonucleotides; Olefins are formed from secondary esters at moderate temperatures. |
Last Update：2024-04-09 02:00:05
